Antoine Chaillon

The paper deconvolves HIV-1 mutational signatures across anatomical compartments and identifies APOBEC3-associated mutagenesis as a major contributor, showing donor-specific patterns.

This study identifies an HIV-1 Tat variant (R52W) that reduces transcriptional activity, potentially contributing to viral persistence during ART.

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.