Author

Weixin Ke

Chinese Academy of SciencesORCID 0000-0002-2192-0485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Linqi WangiD· 3 shared Bing ZhaiiD· 1 shared Bo ZhuiD· 1 shared Chen DingiD· 1 shared Chong Li· 1 shared Chun Feng· 1 shared Cui Hua LiuiD· 1 shared David S. PerliniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

Linqi WangORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The common evolution of fungicide persistence in cryptococcosis patients

Yuyan Xie, Weixin Ke, Xin Fan, Heping Xu, Wenzhao Wang, Zhen Zeng, Na Zhang, Haoran Ma, Zhongjie Tang, Huawei Zhu, Lei Jiang, Bo Zhu, Guohui Shi, Sihan Yang, Minling Yu, , Linqi Wang

The paper identifies common evolutionary events leading to fungicide persistence in Cryptococcus neoformans clinical isolates and shows ACO2 deficiency as a key predictor of high persistence.

bioRxiv · Aug 26, 2026 · PreprintMicrobiology

iCNG99: a validated genome-scale metabolic model of Cryptococcus neoformans strain H99

Chun Feng, Pengjie Hu, Yin Zhu, Weixin Ke, Xindi Gao, Chen Ding, Bing Zhai, Linqi Wang, Ziwei Dai

The paper develops and validates a genome-scale metabolic model for Cryptococcus neoformans strain H99, showing high precision in essential gene prediction and capturing metabolic adaptations relevant to drug tolerance and host survival.

bioRxiv · Apr 15, 2026 · PreprintSystems Biology

Macrophage-derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence

Xiao Chen, Kefan Fang, Бо Ли, Yingxing Li, Yuehua Ke, Weixin Ke, Tian Tian, Yifan Zhao, Linqi Wang, Jing Geng, Mark C. Leake, Fan Bai

This study shows that macrophage-derived ROS induce Salmonella aggresome formation, leading to antibiotic persistence through dormancy and resuscitation capability.

iMeta · Jun 22, 2025Peer-reviewedBiophysics