Jocelyne Leon

This study shows that long-term voluntary exercise in 5xFAD mice leads to limited molecular changes in the hippocampus that do not translate into significant neuroprotection.

This study uses single-nucleus RNA-sequencing to compare transcriptional changes in male and female mouse skeletal muscle during exercise and TFEB overexpression, revealing sex-specific metabolic adaptation mechanisms.

This study shows that enhancing the muscle-to-brain axis in Alzheimer's disease mice reduces amyloid plaques and improves cognitive function through neurotrophic and synaptic signaling.