Constanza J. Cortés

Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice

This study shows that long-term voluntary exercise in 5xFAD mice leads to limited molecular changes in the hippocampus that do not translate into significant neuroprotection.

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle

This study uses single-nucleus RNA-sequencing to compare transcriptional changes in male and female mouse skeletal muscle during exercise and TFEB overexpression, revealing sex-specific metabolic adaptation mechanisms.

Convergent Skeletal Muscle Cytokine Responses to TFEB Overexpression and Voluntary Wheel Running Reflect Sex-Based Variability in Exercise Adaptations

This study compares cytokine responses in male and female mice to TFEB overexpression and voluntary wheel running, revealing sex-based differences in exercise-induced inflammation.

Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points

The paper evaluates changes in glia-neuron communication in 3xTg-AD mice hippocampus at 6 and 12 months, finding increased dysregulation and 23 AD-associated ligand-receptor pairs.

Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer disease mouse model via enhancing neurotrophic and synaptic signaling

This study shows that enhancing the muscle-to-brain axis in Alzheimer's disease mice reduces amyloid plaques and improves cognitive function through neurotrophic and synaptic signaling.

Skeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease

This study shows that enhancing skeletal muscle TFEB signaling reduces neuroinflammation and tau pathology in aging and neurodegenerative disease models.