Ian Matthews

This study uses single-nucleus RNA-sequencing to compare transcriptional changes in male and female mouse skeletal muscle during exercise and TFEB overexpression, revealing sex-specific metabolic adaptation mechanisms.

This study compares cytokine responses in male and female mice to TFEB overexpression and voluntary wheel running, revealing sex-based differences in exercise-induced inflammation.

This study shows that enhancing the muscle-to-brain axis in Alzheimer's disease mice reduces amyloid plaques and improves cognitive function through neurotrophic and synaptic signaling.

This study shows that enhancing skeletal muscle TFEB signaling reduces neuroinflammation and tau pathology in aging and neurodegenerative disease models.