Author

Andrew R. Lynch

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-0238-682XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Peter Van LooiD· 2 shared Adrienne Margaret FlanaganiD· 1 shared Alexander J. LazariD· 1 shared Amy L. BowesiD· 1 shared Angela D. BhallaiD· 1 shared Annelien VerfaillieiD· 1 shared Charles SwantoniD· 1 shared Christina Lynn RolandiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Peter Van LooORCID

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2 papers

Recent·Most cited

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell States

Ryan A. Denu, Zhao Zheng, Yingda Jiang, Suresh Satpati, Veena Kochat, Kumaren Anand, Danh D. Truong, Andrew R. Lynch, William I. Padron, Davis R Ingram, Khalida Wani, Diana Shamsutdinova, Angela D. Bhalla, Sharon M. Landers, Ravin Ratan, , Kunal Rai

This study identifies two epigenetically distinct cell states in leiomyosarcoma using single-nucleus multiome sequencing and spatial transcriptomics, linking them to clinical outcomes and therapeutic vulnerabilities.

bioRxiv · May 26, 2026 · PreprintCancer Biology

The history of chromosomal instability in genome doubled tumors

Toby M. Baker, Siqi Lai, Andrew R. Lynch, Tom Lesluyes, Haixi Yan, Huw A. Ogilvie, Annelien Verfaillie, Stefan C. Dentro, Amy L. Bowes, Nischalan Pillay, Adrienne Margaret Flanagan, Charles Swanton, Paul T. Spellman, Maxime Tarabichi, Peter Van Loo

This paper introduces GRITIC, a method to time genomic gains in tumors, finding that copy number gains often accumulate after genome duplication.

Cancer Discovery · Jun 28, 2024Peer-reviewedGenomics