Author

Paul Rochette

Institut PasteurORCID 0009-0003-1742-6593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Evolutionary Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

David BikardiD· 3 shared Raphaël LaurenceauiD· 3 shared Léo RégnieriD· 2 shared Rémi MonassoniD· 2 shared Simona CoccoiD· 2 shared Amandine Maire· 1 shared Auguste Bouvier· 1 shared Catherine FaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

David BikardORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolutionary BiologyPhysical Review LettersPeer-reviewedOct 26, 2026

Evolutionary Advantage of Diversity-Generating Retroelements in Switching Environments

Léo Régnier, Francesco Amoroso, Paul Rochette…·Rémi Monasson

The paper quantifies the fitness gain of DGR diversification compared to standard mutagenesis and identifies when DGR activation is evolutionarily favored.

DOI 10.1103/xqzp-wpsm

bacteria (other)statistical model

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJun 12, 2026

Computational Design of Optimal Sequences for Targeted Hypermutagenesis Using Recombination-Coupled Diversity-Generating Retroelements

Léo Régnier, Paul Rochette, Raphaël Laurenceau…·Simona Cocco

The paper develops a method to improve DGRec mutagenesis efficiency by recoding templates and using an LSTM model to predict mutational profiles.

DOI 10.64898/2026.06.12.731847

E. colimachine learning (classical)

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintMar 24, 2025

Harnessing Diversity Generating Retroelements for in vivo targeted hyper-mutagenesis

Raphaël Laurenceau, Paul Rochette, Elena Lopez-Rodriguez…·David Bikard

This paper introduces DGRec, a method using DGRs to enable targeted hyper-mutagenesis in E. coli, creating diverse variants that allow evasion of phage infection.

5 citations

E. coliexperimental assay

𝕏 PostBluesky