Raphaël Laurenceau

Evolutionary Advantage of Diversity-Generating Retroelements in Switching Environments

The paper quantifies the fitness gain of DGR diversification compared to standard mutagenesis and identifies when DGR activation is evolutionarily favored.

Shuttling, swapping and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites

The paper identifies and characterizes defence hotspots in P2-like phages and P4-like satellites, revealing rapid modular evolution of antiviral systems through gene swapping and recombination.

Computational Design of Optimal Sequences for Targeted Hypermutagenesis Using Recombination-Coupled Diversity-Generating Retroelements

The paper develops a method to improve DGRec mutagenesis efficiency by recoding templates and using an LSTM model to predict mutational profiles.

Harnessing Diversity Generating Retroelements for in vivo targeted hyper-mutagenesis

This paper introduces DGRec, a method using DGRs to enable targeted hyper-mutagenesis in E. coli, creating diverse variants that allow evasion of phage infection.