Author

Claire E. Shamber

Harvard UniversityORCID 0009-0003-2049-2057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Benjamin P. KleinstiveriD· 1 shared Brandon L. MeyerinkiD· 1 shared C.K. Fong· 1 shared Casey A. MaguireiD· 1 shared Christian Lacks Lino CardenasiD· 1 shared Christiano R. R. AlvesiD· 1 shared David Y. ChungiD· 1 shared Demitri de la Cruz· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioengineering

Benjamin P. KleinstiverORCID

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedSep 11, 2025

In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor

Christiano R. R. Alves, Sabyasachi Das, Vijai Krishnan…·Patricia Leonor Musolino

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

13 citations

mousegenetic perturbation / CRISPR

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NeurosciencebioRxivPreprintJun 18, 2024

AAV-mediated gene transfer of WDR45 corrects neurologic deficits in the mouse model of beta-propeller protein-associated neurodegeneration

Maria Carla Carisi, Claire E. Shamber, Martha Bishop…·Yulia Grishchuk

This study shows that AAV-mediated WDR45 gene transfer rescues neurologic deficits and autophagy defects in a mouse model of BPAN.

DOI 10.1101/2024.06.18.599588

mouseexperimental assay

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