Frank Englert

This paper introduces a method for efficient, single-step genome editing of bacteriophages using targeted DNA nicking, achieving high recombination rates without reducing phage titers.

This study characterizes a type II Thoeris system in E. coli that causes growth arrest without NAD+ depletion, revealing functional diversity within Thoeris types.

This paper uses cell-free transcription-translation to rapidly characterize multi-subunit CRISPR effectors and transposons, revealing new insights into their targeting rules and transposition mechanisms.