Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies
Braden Pate, Anna Goldstein, Madeline Labott, Maria A. Lizarralde-Iragorri, Alisa B. Chankhunthod, Tyonna Tyson, Meghan Sloan, Charith Wijeyesekera, Andrew F. Wilks, Martin H. Steinberg, George J. Murphy, Kim Vanuytsel
This paper uses iPSC-derived erythroid cells to model genetic diversity in sickle cell disease and shows they reflect heterogeneous responses to HbF-inducing therapies like hydroxyurea.
bioRxiv · May 21, 2026 · PreprintCell Biology