Kim Vanuytsel

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies

This paper uses iPSC-derived erythroid cells to model genetic diversity in sickle cell disease and shows they reflect heterogeneous responses to HbF-inducing therapies like hydroxyurea.

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis

This study identifies miR-144 and Hmgn2 as key regulators of chromatin condensation during erythropoiesis, showing their conserved role from fish to humans.

The protein organization of a red blood cell

This study defines the RBC proteome and interactome using mass spectrometry and machine learning, revealing key biological processes and structural models.

RNA LEVER Mediates Long-Range Regulation of ε-globin by Keeping PRC2 in Check

The paper identifies LEVER RNA as a regulator of ε-globin expression by inhibiting PRC2-mediated H3K27 methylation and disrupting promoter-LCR interactions.

DE-NOVO HEMATOPOIESIS FROM THE FETAL LUNG

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.