George J. Murphy

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

This paper creates a high-resolution spatial transcriptomic map of the murine lung's hematopoietic landscape, focusing on megakaryocytes and their interactions with vascular and stromal environments.

This paper uses iPSC-derived erythroid cells to model genetic diversity in sickle cell disease and shows they reflect heterogeneous responses to HbF-inducing therapies like hydroxyurea.

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

The paper establishes a resource of iPSCs from centenarians and their offspring to study human longevity and resilience.

This study identifies miR-144 and Hmgn2 as key regulators of chromatin condensation during erythropoiesis, showing their conserved role from fish to humans.

This study defines the RBC proteome and interactome using mass spectrometry and machine learning, revealing key biological processes and structural models.

The paper identifies LEVER RNA as a regulator of ε-globin expression by inhibiting PRC2-mediated H3K27 methylation and disrupting promoter-LCR interactions.

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.