Doo Eun Choi

This study identifies ZO-2 as a target of c-Abl kinase, showing that c-Abl phosphorylates ZO-2 and regulates cell migration and morphology.

The paper identifies genetic modifiers of somatic CAG expansion and clinical phenotypes in Huntington's disease, revealing shared and tissue-specific effects on disease timing and pathogenic processes.

This study develops personalized CRISPR-Cas9 strategies to specifically inactivate the mutant BAG3 allele in MFM6 patients, demonstrating their feasibility for regenerative medicine.

The paper develops base editing strategies to convert CAG to CAA in Huntington's disease, reducing CAG repeat expansion and showing therapeutic potential.