This paper engineers IgG1 antibodies with modified Fc domains to resist viral Fc receptor binding, enhancing NK cell activation and reducing HCMV spread in infected cells.

7 citationstop 4%

humanproteomics

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MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedSep 18, 2025

Whole Virion Proteomics of HCMV Reveals that gpUL141 is a Virion Component that Regulates Envelope Glycoprotein Composition to Protect Against Humoral Immunity

Kirsten Bentley, Evelina Statkute, Isa Murrell…·Richard James Stanton

This paper identifies gpUL141 as a HCMV virion component that modulates envelope glycoprotein trafficking to evade humoral immunity.

8 citationstop 4%

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 30, 2024

Highly Multiplexed Proteomic Analysis of HCMV-Infected Dendritic Cells Reveals Global Manipulation of Adaptive Immunity and Host Restriction of Viral Replication

Lauren E. Kerr-Jones, Lior Soday, Nia Cwyfan Hughes…·Richard James Stanton

The paper uses proteomic analysis to study HCMV-infected dendritic cells, revealing how the virus manipulates adaptive immunity and restricts replication.

1 citation

humanproteomics

𝕏 PostBluesky