Elizabeth A. Illingworth

Vegfr3 is required in the Tbx1 expression domain for cardiac outflow tract development.

The paper investigates the role of Vegfr3 and Tbx1 in cardiac outflow tract development, finding that Tbx1 modulates Vegfr3's requirement for normal OFT development.

Tbx1 stabilizes differentiation of the cardiopharyngeal mesoderm and drives morphogenesis in the pharyngeal apparatus

The paper investigates the role of Tbx1 in cardiopharyngeal mesoderm differentiation and morphogenesis, finding it stabilizes transcriptional profiles and regulates a conserved gene module.

ENDOTHELIAL GENE REGULATORY ELEMENTS ASSOCIATED WITH CARDIOPHARYNGEAL LINEAGE DIFFERENTIATION

The paper identifies endothelial regulatory elements associated with cardiopharyngeal lineage differentiation using chromatin remodeling data, gene expression, and machine learning.

Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment.

The paper shows that Minoxidil treatment reduces cardiac outflow tract septation defects in a Tbx1 mutant mouse model of DiGeorge syndrome by inhibiting collagen cross-linking.

Tbx1 haploinsufficiency causes brain metabolic and behavioral anomalies in adult mice which are corrected by vitamin B12 treatment

This study shows that Tbx1 haploinsufficiency in mice causes brain metabolic and behavioral issues, which are partially reversed by vitamin B12 treatment.

VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome

This study identifies Vegfr3 as a regulator of brain vessel branching and filopodia formation in a Tbx1 mutant mouse model of 22q11.2 deletion syndrome.

Pharmacological rescue of the brain cortex phenotype in Tbx1 mouse mutants: significance for 22q11.2 deletion syndrome

This study identifies two drugs that rescue the brain cortex phenotype in Tbx1 mutant mice, suggesting potential therapeutic strategies for 22q11.2 deletion syndrome.

Tbx1 interacts genetically with Vegfr3 to regulate cardiac lymphangiogenesis in mice

This study shows that Tbx1 and Vegfr3 interact genetically to regulate cardiac lymphangiogenesis, with dosage balance required for proper vessel development.

Chromatin and transcriptional response to loss of TBX1 in early differentiation of mouse cells.

This study examines the transcriptional and chromatin changes in mouse cells lacking TBX1, finding significant transcriptional effects but limited chromatin remodeling.