Author

Astrid Alvarez de la Cruz

Frederick National Laboratory for Cancer ResearchORCID 0009-0003-5787-8519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Alexandra G. BeilinaiD· 1 shared Juliana A. Martinez FiescoiD· 1 shared Mark CooksoniD· 1 shared Ning LiiD· 1 shared Ping ZhangiD· 1 shared Riley D. MetcalfeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

Alexandra G. BeilinaORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 5, 2025

14-3-3 binding maintains the Parkinson's associated kinase LRRK2 in an inactive state

Juliana A. Martinez Fiesco, Alexandra G. Beilina, Astrid Alvarez de la Cruz…·Ping Zhang

The paper presents the cryo-EM structure of the LRRK2:14-3-32 complex, showing how 14-3-3 binding inhibits LRRK2 activity and how PD mutations disrupt this interaction.

27 citationstop 1%

humanstructural biology

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