Ping Zhang

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

14-3-3 binding maintains the Parkinson's associated kinase LRRK2 in an inactive state

The paper presents the cryo-EM structure of the LRRK2:14-3-32 complex, showing how 14-3-3 binding inhibits LRRK2 activity and how PD mutations disrupt this interaction.

Structure and regulation of full-length human leucine-rich repeat kinase 1

This study reports the cryo-EM structure of LRRK1 and its dimer, revealing structural differences from LRRK2 and providing insights into their regulation.