Author

Juliana A. Martinez Fiesco

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-2396-0974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Ping ZhangiD· 3 shared Mark CooksoniD· 2 shared Riley D. MetcalfeiD· 2 shared Alexandra G. BeilinaiD· 1 shared Alexandria L. SohniD· 1 shared Andrew G. StepheniD· 1 shared Astrid Alvarez de la CruziD· 1 shared Caroline J. DeHartiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Ping ZhangORCID

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3 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 15, 2025

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State

Daniel A. Ritt, David Durrant, Matthew R. Drew…·Deborah K. Morrison

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

9 citations

experimental assay

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BiochemistryNature CommunicationsPeer-reviewedAug 5, 2025

14-3-3 binding maintains the Parkinson's associated kinase LRRK2 in an inactive state

Juliana A. Martinez Fiesco, Alexandra G. Beilina, Astrid Alvarez de la Cruz…·Ping Zhang

The paper presents the cryo-EM structure of the LRRK2:14-3-32 complex, showing how 14-3-3 binding inhibits LRRK2 activity and how PD mutations disrupt this interaction.

27 citationstop 1%

humanstructural biology

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Molecular BiologyNature CommunicationsPeer-reviewedAug 9, 2023

Structure and regulation of full-length human leucine-rich repeat kinase 1

Riley D. Metcalfe, Juliana A. Martinez Fiesco, Luis Bonet‐Ponce…·Ping Zhang

This study reports the cryo-EM structure of LRRK1 and its dimer, revealing structural differences from LRRK2 and providing insights into their regulation.

8 citations

humanexperimental assay

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