Jarryd Ramborger

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

The paper identifies incentive salience as the driver of cocaine self-administration escalation in rats, showing individual differences in pre-lever activity predict long-term intake.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The paper describes a scalable, low-cost video recording system for simultaneous animal behavior monitoring in operant chambers, achieving high throughput and fidelity with minimal storage.