Yury S. Bykov

This study shows that mitochondrial presequences function in cytosolic quality control and trigger a heat shock response when mitochondrial import is inhibited.

The paper shows that Vms1 protects mitochondrial import and homeostasis during translation stress by interacting with Msp1.

The paper develops hMultiCLEM, a high-resolution screening pipeline combining EM and multiplexed human cell pools to identify proteins affecting mitochondrial cristae shape, uncovering MISHA linked to Meniere's disease.

The paper uses a bi-genomic split-GFP assay to identify mitochondrial matrix and inner membrane proteins, revealing 50 previously unvisualized proteins and characterizing dually localized proteins.