Joshua Mallen

This study presents a transcriptomic atlas of the developing human outflow tract and its adult aortic valve derivatives, revealing persistent embryonic signatures and key regulatory factors in valve development.

The paper shows MEIS transcription factors are essential for activating cardiac-specific gene expression by working with lineage-restricted TFs to drive cardiac differentiation.

The paper identifies TEAD1 as a repressor of tissue-specific transcription factors in human organ development by analyzing combinatorial TF binding in enhancers.

The paper investigates how HOX paralogs interact with TALE TFs to generate tissue-specific enhancer activation patterns in mouse embryos.