Author

Rotem Leshem

University of ManchesterORCID 0000-0002-8916-9843Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adam F. L. HurlstoneiD· 1 shared Andrew D SharrocksiD· 1 shared Charlotte E Taylor BarcaiD· 1 shared Chun Wai WongiD· 1 shared Dervla T. IsaaciD· 1 shared Gareth Wyn JonesiD· 1 shared I‐Hsuan LiniD· 1 shared John Henry DarkiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Adam F. L. HurlstoneORCID

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3 papers

Recent·Most cited

A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives

Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Henry Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A. Hanley, Magnus Rattray, Simon D. Bamforth, Nicoletta Bobola

This study presents a transcriptomic atlas of the developing human outflow tract and its adult aortic valve derivatives, revealing persistent embryonic signatures and key regulatory factors in valve development.

eLife · Jun 25, 2026Peer-reviewedDevelopmental Biology

Travelling Waves in Gene Expression: A Mathematical Model of Cell-State Dynamics in Melanoma

Charlotte E Taylor Barca, Rotem Leshem, Vishaka Gopalan, Sarah Woolner, Kerrie L. Marie, Gareth Wyn Jones, Oliver E. Jensen

The paper develops a mathematical model to study gene-expression dynamics and cell-state switching in melanoma using deterministic differential equations and cooperative binding approximations.

Bulletin of Mathematical Biology · Jun 8, 2026Peer-reviewedCancer Biology

Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarisation in Relapsed Melanoma

Rotem Leshem, Kieran N. Sefton, Chun Wai Wong, I‐Hsuan Lin, Dervla T. Isaac, Mario Niepel, Adam F. L. Hurlstone

This paper shows that combining PARP14 inhibition with PD-1 blockade enhances immune responses in melanoma by promoting T cell quiescence and modulating macrophage polarization.

Journal for ImmunoTherapy of Cancer · Jan 1, 2025Peer-reviewedCancer Biology