Weizhe Wang

The paper introduces Cerebra-Epistasis, a framework that improves multi-mutant fitness prediction by modeling epistatic effects and integrating structure-aware sequence analysis.

This study identifies TRIM72's protective role in ALS through both cell-autonomous and non-cell-autonomous mechanisms, showing its therapeutic potential in animal models and human patients.

Cerebra improves computational efficiency in protein structure prediction while maintaining accuracy, achieving comparable performance to optimized models with fewer resources.