Author

Ruth Cruz‐Cosme

Howard UniversityORCID 0009-0003-8400-5721Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Qiyi TangiD· 4 shared Shaolei TengiD· 2 shared Alexander StevensiD· 1 shared Iftikhar MuhammadiD· 1 shared J. Marc SimardiD· 1 shared Jiantao ZhangiD· 1 shared Junyan LiiD· 1 shared Kaci CraftiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

Qiyi TangORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 10, 2026

Hepatitis C Virus Remodels Lipid Droplets to Promote Mitochondrial Fatty Acid Accumulation and Metabolic Activation

Iftikhar Muhammad, Kaci Craft, Shaokai Pei…·Qiyi Tang

This paper investigates how HCV remodels lipid droplets during infection, leading to mitochondrial fatty acid accumulation and metabolic activation, with implications for antiviral strategies.

DOI 10.64898/2026.07.09.737644

humanbulk RNA-seq

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MicrobiologyJournal of VirologyPeer-reviewedJan 30, 2026

Computational and Experimental Identification of Potential Neutralizing Peptides Derived from Human ACE2 Against SARS-CoV-2 Infection

Qiaobin Yao, Vidhyanand Mahase, Wangheng Hou…·Shaolei Teng

This study identifies six ACE2 regions and peptides that can neutralize SARS-CoV-2, showing computational and experimental consistency across variants.

DOI 10.1128/jvi.01468-25

humanproteomics

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MicrobiologyVirologyPeer-reviewedMay 17, 2024

Structure-Guided Mutagenesis Targeting Interactions between pp150 Tegument Protein and Small Capsid Protein Identify Five Lethal and Two Live Attenuated HCMV Mutants

Alexander Stevens, Ruth Cruz‐Cosme, Najealicka Armstrong…·Z. Hong Zhou

The paper identifies five lethal and two live attenuated HCMV mutants by mutating pp150-capsid interactions, revealing critical residues for viral replication.

3 citations

humanexperimental assay

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Molecular BiologymBioPeer-reviewedFeb 15, 2022

Genome-wide characterization of SARS-CoV-2 cytopathogenic proteins in the search of antiviral targets

Jiantao Zhang, Qi Li, Ruth Cruz‐Cosme…·Yuqi Zhao

The paper identifies twelve SARS-CoV-2 proteins that induce oxidative stress, inflammation, and cell death, with ORF3a highlighted as a promising antiviral target for drug discovery.

32 citationstop 5%

humanexperimental assay

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