Antonella F. M. Dost

A human organoid model of alveolar regeneration reveals distinct epithelial responses to interferon-gamma

This study develops a human organoid model to investigate interferon-gamma's effects on alveolar epithelial cell regeneration, showing divergent impacts on AT1 and AT2 cells.

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

Mapping the complete influenza A virus infection cycle through single vRNP imaging

This study maps the complete influenza A virus infection cycle in individual cells, identifying key factors driving infection heterogeneity.

Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axis

This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.

COOBoostR: an extreme gradient boosting-based tool for robust tissue or cell-of-origin prediction of tumors

COOBoostR uses extreme gradient boosting to predict tumor tissue or cell-of-origin using chromatin marks and mutation density data, outperforming random forest methods in speed and accuracy.