Author

Shaun Moore

Artios Pharma Limited (United Kingdom)ORCID 0009-0003-9317-8632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandro CicconiiD· 1 shared Anca M. FarcasiD· 1 shared Anob M. ChakrabartiiD· 1 shared Asmita Thapa· 1 shared Aurora CeruttiiD· 1 shared Bethany Rebekah Hill· 1 shared Célia GotorbeiD· 1 shared Charlotte CapitanchikiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alessandro CicconiORCID

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedJun 12, 2026

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy

Gonzalo Rodríguez‐Berriguete, Purusotha Thambiayah, Alessandro Cicconi…·Geoff Stuart Higgins

The paper identifies SHLD2 loss as a vulnerability that enhances radiosensitisation when combined with Polθ inhibition in cancer cells.

DOI 10.1126/sciadv.aeb4508

humangenetic perturbation / CRISPR

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Molecular BiologybioRxivPreprintMar 6, 2025

PRMT activity promotes global 3' UTR shortening in proliferating cells

Llywelyn Griffith, Charlotte Capitanchik, Shaun Moore…·Jernej Ule

This study shows PRMT activity regulates 3' UTR shortening in proliferating cells through alternative polyadenylation, impacting cancer and immune-related diseases.

DOI 10.1101/2025.03.06.641848

humanbulk RNA-seq

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