Matthew Edward Thornton

This study identifies mGluR6's role in human retinal development by showing its transient expression in cone photoreceptors and its requirement for proper synaptic layer assembly.

The paper demonstrates that human nephron cells can switch between proximal and distal identities through WNT, FGF, and BMP signaling, showing developmental plasticity.

The paper identifies and characterizes early human photoreceptor states and cell-state-specific features related to retinoblastoma using single-cell RNA sequencing.

This study defines axial nephron patterning in human kidney organoids by using synthetic Wnt-secreting organizers to mimic developmental signals and achieve in vivo-like polarity.

This paper develops a method to generate proximal tubule precursor cells in kidney organoids using transient Notch signaling activation, showing functional maturity and injury response.

This study identifies defective mesenchymal Bmpr1a-mediated BMP signaling as a cause of congenital pulmonary cysts by disrupting lung branching morphogenesis and airway structure.

The paper identifies a novel population of cardiac lymphatic endothelial cells in human fetal hearts associated with coronary arteries using single nuclei multiomic analysis.

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

The paper generates kidney collecting duct organoids from ureteric bud progenitors and stem cells to study development and disease of the collecting system.