Nina Graffmann

SAHA increases chaperone expression and reduces Z-alpha-1-antitrypsin polymers in a patient specific iPSC-based liver model for alpha-1-antitrypsin deficiency

The paper uses iPSC-derived liver cells to show SAHA reduces Z-alpha-1-antitrypsin polymers by increasing chaperone expression in AATD models.

DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCs

This study shows DPP4 inhibition alters metabolism and inflammation pathways in steatotic hiPSC-derived HLCs, suggesting potential therapeutic benefits for MAFLD.

Human CSB-deficient iPSCs exhibit impaired DNA damage repair and stress responses following BPDE exposure in an early developmental model.

This study shows that CSB-deficient iPSCs have impaired DNA repair and stress responses after BPDE exposure, highlighting CSB's role in genome stability during development.

Investigating BPDE-induced embryonic toxicity employing hiPSC-based models

This study examines BPDE toxicity in hiPSCs and NPCs, revealing hiPSCs are more sensitive to BPDE with enhanced p53-mediated DNA damage response, and NBS patient cells show reduced apoptosis.

Investigation of Thyroid Hormone Associated Gene-Regulatory Networks during Hepatogenesis using an Induced Pluripotent Stem Cell based Model

This study uses thyroid hormones to mature hepatocyte-like cells derived from iPSCs, showing improved expression of adult markers and reduced fetal markers.

A Comprehensive Molecular Portrait of Human Urine-derived Renal Progenitor Cells

This paper identifies and characterizes human urine-derived renal progenitor cells, revealing their molecular identity, reprogramming potential, and gene regulatory mechanisms for self-renewal and differentiation.