Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis
Xiaowen Ma, Xiaoli Wei, Mengwei Niu, Chen Zhang, Zheyun Peng, Wanqing Liu, Junrong Yan, Xiaoyang Su, Shaolei Lu, Wei Cui, Hiromi Sesaki, Wei‐Xing Zong, Hong‐Min Ni, Wen‐Xing Ding
This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.
bioRxiv · Feb 11, 2025 · PreprintCell Biology