This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Biomedicine & Pharmacotherapy · Mar 23, 2025Peer-reviewedCancer Biology

Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis

Xiaowen Ma, Xiaoli Wei, Mengwei Niu, Chen Zhang, Zheyun Peng, Wanqing Liu, Junrong Yan, Xiaoyang Su, Shaolei Lu, Wei Cui, Hiromi Sesaki, Wei‐Xing Zong, Hong‐Min Ni, Wen‐Xing Ding

This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.

bioRxiv · Feb 11, 2025 · PreprintCell Biology

Late-Life Alcohol Exposure Does Not Exacerbate Age-Dependent Reductions in Mouse Spatial Memory and Brain TFEB Activity

Hao Chen, Kaitlyn Hinz, Chen Zhang, Yssa Rodriguez, Sha Neisha Williams, Mengwei Niu, Xiaowen Ma, Xiaojuan Chao, Alexandria L. Frazier, Kenneth E. McCarson, Xiaowan Wang, Zheyun Peng, Wanqing Liu, Hong‐Min Ni, Jianhua Zhang, , Wen‐Xing Ding

This study examines the effects of late-life alcohol exposure on spatial memory and TFEB activity in young and aged mice, finding that aging has a greater impact than alcohol.

Biomolecules · Nov 30, 2024Peer-reviewedAnimal Behavior & Cognition