Author

Sarah N. Obeidalla

Vanderbilt University Medical CenterORCID 0009-0004-0832-1527Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Casey M. NicholsiD· 2 shared Chooi Ying Sim· 2 shared Dawn C. NewcombiD· 2 shared Erin L. Mwizerwa· 2 shared Jeffrey C. RathmelliD· 2 shared Julie A. BastaracheiD· 2 shared Lorraine B. WareiD· 2 shared Matthew T. StieriD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Casey M. NicholsORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 2, 2026

Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality

C. Mark Nichols, Erin L. Mwizerwa, Chooi Ying Sim…·Matthew T. Stier

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

DOI 10.64898/2026.05.28.728555

humanscRNA-seq

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ImmunologyNature ImmunologyPeer-reviewedJan 15, 2026

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis

Matthew T. Stier, Allison E. Sewell, Erin L. Mwizerwa…·Jeffrey C. Rathmell

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

17 citationstop 1%

humanbulk RNA-seq

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