Author

Chooi Ying Sim

Vanderbilt University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Casey M. NicholsiD· 2 shared Dawn C. NewcombiD· 2 shared Erin L. Mwizerwa· 2 shared Jeffrey C. RathmelliD· 2 shared Julie A. BastaracheiD· 2 shared Lorraine B. WareiD· 2 shared Matthew T. StieriD· 2 shared Sarah N. ObeidallaiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Casey M. NicholsORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality

C. Mark Nichols, Erin L. Mwizerwa, Chooi Ying Sim, Sarah N. Obeidalla, Jacqueline-Yvonne Cephus, Caroline E. Roe, Jonathan Michael Irish, Dawn C. Newcomb, Vern Eric Kerchberger, Julie A. Bastarache, Jeffrey C. Rathmell, Lorraine B. Ware, Matthew T. Stier

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

bioRxiv · Jun 2, 2026 · PreprintImmunology

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis

Matthew T. Stier, Allison E. Sewell, Erin L. Mwizerwa, Chooi Ying Sim, Steve Tanner, Casey M. Nichols, Heather H. Durai, Erin Q. Jennings, Paul Lindau, Erin M. Wilfong, Sarah N. Obeidalla, Vern Eric Kerchberger, Dawn C. Newcomb, Julie A. Bastarache, Lorraine B. Ware, Jeffrey C. Rathmell

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

Nature Immunology · Jan 15, 2026Peer-reviewedImmunology