Julie A. Bastarache

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

This study shows that older mice experience more severe sepsis with higher inflammation, vascular permeability, and organ damage compared to younger mice.