Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality
C. Mark Nichols, Erin L. Mwizerwa, Chooi Ying Sim, Sarah N. Obeidalla, Jacqueline-Yvonne Cephus, Caroline E. Roe, Jonathan Michael Irish, Dawn C. Newcomb, Vern Eric Kerchberger, Julie A. Bastarache, Jeffrey C. Rathmell, Lorraine B. Ware, Matthew T. Stier
The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.
bioRxiv · Jun 2, 2026 · PreprintImmunology