Dawn C. Newcomb

The paper classifies human Th17 cells into non-pathogenic and pathogenic states and identifies acylcarnitine metabolism as a vulnerability in type 2 diabetes.

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

The paper identifies immune cell dysfunction in adipose tissue of individuals with obesity-associated asthma using single-cell RNA sequencing.

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

This study shows that estrogen receptor-alpha signaling in T cells increases Th17-mediated airway inflammation in obese female mice and that Th17 cells are more frequent in women with asthma compared to men.

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

This study shows Th2 cell extracellular vesicles carry IL-3, which promotes eosinophil survival and prolongs airway eosinophilia during allergic inflammation.

The paper maps single-cell immune responses to F. tularensis infection in mice, identifying MAIT cells as key to IL-17-dependent protection against tularemia-like disease.

This study identifies cell type-specific DNA methylation changes in airway epithelial cells linked to early-life RSV infection and their association with subsequent wheezing.

The paper uses single-cell RNA sequencing to study how wheeze and early-life RSV infection affect airway epithelial development in children.