Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding
Manjari Prakash, Yean Ming Chew, Denisa Ondruskova, Jiří Mikšátko, Alica Dodoková, Arya Krishnan, Carsten Janke, Robert Anthony Cross, Zdeněk Lánský, Marcus Braun
The paper shows that co-polymerization of different tubulin isotypes creates sectioned microtubules that differentially bind MAPs like TPPP1 and OPTN.
bioRxiv · Mar 12, 2025 · PreprintCell Biology