Gabrielle E. Largoza

The paper introduces MAGIC, a cloning system enabling modular assembly of gene constructs for use in vertebrate models.

This study shows that KRAS mutations drive brain arteriovenous malformations (bAVMs) in specific brain regions and that MEK inhibition can reduce their severity in mice, suggesting a potential therapeutic approach for human bAVMs.

This study identifies transcriptional and epigenetic mechanisms driving endothelial diversity across organs in mice, revealing conserved gene regulatory networks in the brain vasculature.