Marc Gabriel

Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C

This study shows that the p53Y217C mutation causes inflammation, leading to oncogenic effects in male mice and teratogenic effects in female mice, with anti-inflammatory treatment improving female survival.

Blind exploration of the unreferenced transcriptome reveals novel RNAs for prostate cancer diagnosis

The paper introduces a reference-free computational method to identify novel RNAs for prostate cancer diagnosis, finding that 9 unannotated lncRNAs outperform existing biomarkers.

Exhaustive capture of biological variation in RNA-seq data through k-mer decomposition

This paper introduces DE-kupl, a k-mer-based method to capture RNA variation without a reference, identifying novel transcripts and biological events from RNA-seq data.

In plants, decapping prevents RDR6-dependent production of small interfering RNAs from endogenous mRNAs

The paper shows that decapping prevents RDR6-dependent production of rqc-siRNAs from endogenous mRNAs, revealing a link between RNA quality control and post-transcriptional gene silencing in plants.