Raphaël Rodriguez

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

The paper links lower plasma plasmalogen levels to increased risk of lymph node positive breast cancer in humans and mice, showing dietary PUFA depletion promotes cancer survival in lymph nodes.

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

This study shows that the p53Y217C mutation causes inflammation, leading to oncogenic effects in male mice and teratogenic effects in female mice, with anti-inflammatory treatment improving female survival.