Author

Maren Köhne

German Center for Neurodegenerative DiseasesORCID 0009-0004-1689-6734Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Axel KalliesiD· 3 shared Collins Osei-SarpongiD· 3 shared Elena De DomenicoiD· 3 shared Lorenzo BonaguroiD· 3 shared Marc BeyeriD· 3 shared Tarek ElmzzahiiD· 3 shared Aleksej Frolov· 2 shared Darya MalkoiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Axel KalliesORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Downregulation of Satb1 is required to prevent autoimmunity by maintaining Tfh homeostasis

Mehrnoush Hadaddzadeh Shakiba, Maren Köhne, Tarek Elmzzahi, Luisa Bach, Doaa Hamada, Leonie Heyden, Anna F. Lindemann, Jannis Bastian Spintge, Aleksej Frolov, Yuanfang Li, Lisa Holsten, Marlene Gottschalk, Celia Kho, Darya Malko, Collins Osei-Sarpong, , Marc Beyer

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

bioRxiv · Feb 5, 2026 · PreprintImmunology

Molecular determinants of brain-resident CD8+ T cell formation and function

Tarek Elmzzahi, Chun-Hsi Su, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Darya Malko, Maren Köhne, Aleksej Frolov, Teisha Mason, Rebekka Scholz, Yuanfang Li, Collins Osei-Sarpong, Leonie Heyden, Jonas Schulte-Schrepping, Lorenzo Bonaguro, Kristian Händler, , Marc Beyer

This study identifies molecular factors shaping brain-resident CD8+ T cell formation and function in health and disease.

bioRxiv · Aug 26, 2025 · PreprintImmunology

Disease-associated microglia and activation of CD8+ T cells precede neuronal cell loss in a model of hereditary spastic paraplegia

Aleksej Frolov, Hao Huang, Dagmar Schütz, Maren Köhne, Nelli Blank-Stein, Collins Osei-Sarpong, Maren Büttner, Tarek Elmzzahi, Mukhran Khundadze, Marina Zahid, Michael Reuter, Matthias Becker, Elena De Domenico, Lorenzo Bonaguro, Axel Kallies, , Marc Beyer

The Journal of Experimental Medicine · Mar 20, 2025Peer-reviewedImmunology