Author

Luisa Bach

University of BonnORCID 0000-0002-3476-6325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

Dirk BaumjohanniD· 3 shared Eva KiermaieriD· 2 shared Felix MeissneriD· 2 shared Peter KonopkaiD· 2 shared Shaunak GhoshiD· 2 shared Zeinab AbdullahiD· 2 shared Aleksej Frolov· 1 shared Andreas W. ThomaeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Dirk BaumjohannORCID

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3 papers

Recent·Most cited

Downregulation of Satb1 is required to prevent autoimmunity by maintaining Tfh homeostasis

Mehrnoush Hadaddzadeh Shakiba, Maren Köhne, Tarek Elmzzahi, Luisa Bach, Doaa Hamada, Leonie Heyden, Anna F. Lindemann, Jannis Bastian Spintge, Aleksej Frolov, Yuanfang Li, Lisa Holsten, Marlene Gottschalk, Celia Kho, Darya Malko, Collins Osei-Sarpong, , Marc Beyer

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

bioRxiv · Feb 5, 2026 · PreprintImmunology

Multiple clustered centrosomes in antigen-presenting cells foster T cell activation without MTOC polarization

Isabel Stötzel, Ann-Kathrin Weier, Apurba Sarkar, Subhendu Som, Luisa Bach, Peter Konopka, Eliška Miková, Shaunak Ghosh, Jan Böthling, Mirka Homrich, Laura Schaedel, Uli Kazmaier, Konstantinos Symeonidis, Stefan Ebner, Philip Weidner, , Eva Kiermaier

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

Nature Communications · Jan 13, 2026Peer-reviewedCell Biology

Mechanical Centrosome Fracturing during Cell Navigation

Madeleine T. Schmitt, Janina Kroll, Mauricio J.A. Ruiz-Fernandez, Robert Hauschild, Shaunak Ghosh, Petra Kameritsch, Jack Merrin, Johanna Schmid, Kasia Stefanowski, Andreas W. Thomae, Jingyuan Cheng, Gamze Naz Öztan, Peter Konopka, Germán Camargo Ortega, Thomas Penz, , Jörg Renkawitz

The paper shows that centrosomes in non-dividing cells can fracture under mechanical stress during cell navigation, and Dyrk3 prevents this fracturing to maintain cellular function.

Science Advances · Apr 25, 2025Peer-reviewedCell Biology