Cancer BiologybioRxivPreprint
Hypobaric hypoxia drives citrate cycle reprogramming to suppress tumor progression
Yixing Gao, Xiuju He, E Guoji…·Erlong Zhang
This study shows hypobaric hypoxia suppresses tumor progression by reprogramming the citrate cycle and inhibiting the HIF-1 pathway, enhancing antitumor immune response and improving therapy outcomes.