Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways
Tatiana M. Moreno, Michelle E Brown, Caitlin M. Lange, Gavin C McLaren, Diego A Hernandez-Urbina, Cheng‐Ju Kuo, Caroline Kumsta
This study shows that heat shock activates HLH-30/TFEB independently of mTORC1 and AMPK, revealing stress-specific regulation of this transcription factor.
bioRxiv · Sep 3, 2026 · PreprintCell Biology