Caroline Kumsta

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

This study shows that heat shock activates HLH-30/TFEB independently of mTORC1 and AMPK, revealing stress-specific regulation of this transcription factor.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

This study examines autophagy flux changes with age in human cell types, finding sex- and cell-type-specific patterns and a link to physical fitness.

The paper introduces PathStAR, a framework to quantify structural aging from histopathology images, revealing tissue-specific aging trajectories and coordinated deterioration across organs.

The paper shows that reduced nucleosome stability impairs cell identity, stress resilience, and healthy aging across species.

This study shows that neuropeptides regulate intestinal integrity and aging in invertebrates, with effects modulated by the germline.