Tatiana M. Moreno

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

This study shows that heat shock activates HLH-30/TFEB independently of mTORC1 and AMPK, revealing stress-specific regulation of this transcription factor.

This study examines autophagy flux changes with age in human cell types, finding sex- and cell-type-specific patterns and a link to physical fitness.

The paper shows that reduced nucleosome stability impairs cell identity, stress resilience, and healthy aging across species.