Author

Lisa-Marie Krammer

Graz University of TechnologyORCID 0009-0008-1499-441XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:phylogenetics / evolution· 1 Assay:protein sequence· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Elske van der PoliD· 2 shared Robert KouristiD· 2 shared Colin Schür· 1 shared Dominik GrossiD· 1 shared Gyula HoffkaiD· 1 shared J. EderiD· 1 shared Jan Georg GerstenbergeriD· 1 shared Kenji MiyamotoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Elske van der PolORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 20, 2026

✦ In-depth digest

Ancestors of Arylmalonate Decarboxylase show increased Activity, Stability and Stereoselectivity

Elske van der Pol, Jan Georg Gerstenberger, Xenia Georgiadou…·Robert Kourist

Ancestral sequence reconstruction of a bacterial decarboxylase gave enzymes with up to 294-fold longer half-life at 45 °C, higher activity, and 99.7% ee on a vinyl malonate substrate.

2 citations

bacteria (other)protein sequence

𝕏 PostBluesky

BiochemistryChemical CommunicationsPeer-reviewedJan 1, 2026

Hydrophobic pocket engineering of arylmalonate decarboxylase expands its substrate scope towards the synthesis of the (R)-enantiomers of sterically hindered carboxylic acids

Elske van der Pol, Lisa-Marie Krammer, J. Eder…·Robert Kourist

This study modifies arylmalonate decarboxylase to expand its substrate scope for synthesizing (R)-enantiomers of sterically hindered carboxylic acids with high enantiopurity.

DOI 10.1039/d6cc02837c

experimental assayprotein folding & dynamics

𝕏 PostBluesky