Guorong Li

Molecular profiling implicates immune-driven adaptive homeostasis in maintaining intraocular pressure with age

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

Segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model

This study examines how dexamethasone-induced ocular hypertension affects segmental outflow and trabecular meshwork stiffness in mice, finding no significant stiffness differences but increased fibronectin in low-flow regions.

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.