Paolo Capriotti

This study develops and characterizes a nanosd integral gene drive in Anopheles gambiae, achieving high gene drive rates and showing potential for malaria vector control.

This study overexpresses REL2 in Anopheles gambiae midgut and finds it causes transcriptional changes but does not induce a strong immune response against Plasmodium falciparum.

The paper develops a gene drive effector that retards Plasmodium development in transgenic Anopheles gambiae mosquitoes via midgut antimicrobial peptides, predicted to eliminate malaria across transmission scenarios.

This paper converts endogenous mosquito genes into non-autonomous gene drives for malaria control by using native regulatory sequences to express antimalarial molecules and guide-RNAs.

This study evaluates synthetic reproductive barriers in Drosophila using CRISPR and CRISPRa, finding that synthetic lethality is achievable but with trade-offs in genetic isolation and fly fitness.