Astrid Hoermann

The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae

This study develops and characterizes a nanosd integral gene drive in Anopheles gambiae, achieving high gene drive rates and showing potential for malaria vector control.

REL2 overexpression in the Anopheles gambiae midgut causes major transcriptional changes but fails to induce an immune response

This study overexpresses REL2 in Anopheles gambiae midgut and finds it causes transcriptional changes but does not induce a strong immune response against Plasmodium falciparum.

Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development

The paper develops a gene drive effector that retards Plasmodium development in transgenic Anopheles gambiae mosquitoes via midgut antimicrobial peptides, predicted to eliminate malaria across transmission scenarios.

Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

This paper converts endogenous mosquito genes into non-autonomous gene drives for malaria control by using native regulatory sequences to express antimalarial molecules and guide-RNAs.

Integral Gene Drives: an \"operating system\" for population replacement

This paper evaluates Integral Gene Drive (IGD) as a more durable and flexible alternative to classical gene drives for population replacement, showing reduced resistance and prolonged transmission blockage.